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201904151249411

UGT1A1-MAMAPCR real time

Quantification assay of UGT1A1 gene polymorphism G211A markers of Gilbert’s Syndrome          cod. BM-012

Principle of the test : Genotypes exon 1 G211A of UGT1A1

Technology: MAMAPCR Real Time

Gene Target: UGT1A1

Specimen: DNA

Results: Genotype

Number of tests: 25 tests BM-012 

Kit storage: -20°C

Necessary equipment: 7500 Real Time PCR System

Status: Ready to use

 

UGT1A1-MAMAPCR real time  cod. BM-012​

 

Quantification assay of UGT1A1 gene polymorphism G211A markers of Gilbert’s Syndrome

 

·      UGT1A1-MAMAPCR real time complete kit 25 tests BM-012

 

Gilbert’s syndrome is a mild disorder that occurs in up to 8% of the population in which bilirubin in the blood builds up to levels that are higher than normal. Bilirubin is a yellow waste product that results from the breakdown of old red blood cells. The major genetic variants underlying Gilbert's syndrome are TATA-box repeats of the promoter region and exon 1 G211A of the coding region, particularly in Asians24. The mutation at nucleotide 211 (G211A) that causes arginine to replace glycine at position 71 in the coding region of the UGT1A1 gene is responsible for approximately 20% of Gilbert’s syndrome cases in Asian subjects.

We have established a novel analysis able to genotypes exon 1 G211A of the coding region. This method is based on real-time PCR. A genetic test for Gilbert’s syndrome would provide a positive diagnosis for this condition and may, in theory, aid in the management of a patient found to have an isolated increased bilirubin. User friendly and complete, the UGT1A1 gene polymorphism G211A PCR real time detection kit is suitable for any laboratory.

 

Reference

1.      Hsieh TY, Shiu TY, Chu NF, Chao TY, Chu HC, Chang WK, Chao YC, Huang HH. Rapid molecular diagnosis of the Gilbert's syndrome-associated exon 1 mutation within the UGT1A1 gene. Genet Mol Res. 2014 Jan 28;13(1):670-9. doi: 10.4238/2014.